Molecular characterization of muscarinic receptor subtypes in bovine cerebral cortex.
نویسندگان
چکیده
منابع مشابه
In vivo characterization of vasodilating muscarinic-receptor subtypes in humans.
The role of muscarinic (M)-receptor subtypes in the regulation of vascular tone has not yet been defined in humans. To analyze the role of M-receptor subtypes in the forearm resistance vasculature of normotensive volunteers (n = 20), we infused acetylcholine (ACh) and methacholine (MCh) in the presence of saline and the antagonists atropine (nonselective), pirenzepine (M1 selective), and AF-DX ...
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Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...
متن کاملMuscarinic receptor subtypes in airways.
Muscarinic receptor subtypes in the airways appear to subserve different physiological functions. M1-receptors facilitate neurotransmission through parasympathetic ganglia and enhance cholinergic reflexes, but are also localized to alveolar walls. M2-receptors act as autoreceptors on post-ganglionic cholinergic nerves and inhibit acetylcholine release. There is some evidence that they may be de...
متن کاملPharmacological and molecular characterization of muscarinic receptor subtypes in human esophageal smooth muscle.
Esophageal peristalsis is dependent on activation of muscarinic receptors, but little is known about the roles of specific receptor subtypes in the human esophagus. We examined muscarinic receptor expression and function in human esophageal smooth muscle obtained from patients undergoing resection for cancer. [(3)H]Quinuclidinyl benzylate (QNB)-specific binding was similar in longitudinal muscl...
متن کاملMuscarinic receptor subtypes in the alimentary tract.
Acetylcholine is a transmitter in preganglionic autonomic and postganglionic parasympathetic nerves and a non-neuronal paracrine mediator in the alimentary tract. Acetylcholine is involved in the control of almost any function within these organ systems, and almost every cell type expresses multiple muscarinic receptor subtypes. Although muscarinic receptors at non-neuronal effector cells commo...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1985
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)63322-6